SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

VEGFR2 is a central regulator of angiogenesis. Here Zhou et al. report that SUMOylation of VEGFR2 regulates its subcellular localisation and activity, and that endothelial-specific knockout of the SUMO endopeptidase SENP1 protects against VEGFR2-mediated pathological angiogenesis.

Bibliographic Details
Main Authors: Huanjiao Jenny Zhou, Zhe Xu, Zongren Wang, Haifeng Zhang, Zhen W. Zhuang, Michael Simons, Wang Min
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05812-2

Internet

https://doi.org/10.1038/s41467-018-05812-2

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