Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury

Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury

Traumatic brain injury (TBI) is strongly linked to an increased risk of developing dementia, including chronic traumatic encephalopathy and possibly Alzheimer's disease (AD). APOEε4 allele of human Apolipoprotein E (APOE) gene is the major genetic risk factor for late onset AD and has been asso...

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Bibliographic Details
Main Authors: Emilie L. Castranio, Anais Mounier, Cody M. Wolfe, Kyong Nyon Nam, Nicholas F. Fitz, Florent Letronne, Jonathan Schug, Radosveta Koldamova, Iliya Lefterov
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
Apolipoprotein E
Traumatic brain injury
Trem2
Tyrobp
Myelination
Immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301092

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http://www.sciencedirect.com/science/article/pii/S0969996117301092

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