High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

Abstract Background Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this proce...

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Bibliographic Details
Main Authors: Pei Li, Gang Hou, Ruijie Zhang, Yibo Gan, Yuan Xu, Lei Song, Qiang Zhou
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Arthritis Research & Therapy
Subjects:
Compression
Senescence
Nucleus pulposus cell
p38 MAPK
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s13075-017-1384-z

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http://link.springer.com/article/10.1186/s13075-017-1384-z

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