Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation

Under physiological conditions, CD4+ regulatory T (Treg) cells expressing the transcription factor Foxp3 are generated in the thymus [thymus-derived Foxp3+ Treg (tTregs) cells] and extrathymically at peripheral sites [peripherally induced Foxp3+ Treg (pTreg) cell], and both developmental subsets pla...

Full description

Bibliographic Details
Main Authors: Kristin Freudenberg, Nadja Lindner, Sebastian Dohnke, Annette I. Garbe, Sonja Schallenberg, Karsten Kretschmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
epigenetic regulation
iTreg
Foxp3
DNA methylation
CNS2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00125/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00125/full

Similar Items