Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

Abstract Background Microglia are known as resident immune cells in the brain. β-amyloid (Aβ) plaques in the brain of Alzheimer’s disease (AD) are surrounded by microglia, but whether and how microglia affect the formation and maintenance of plaques remains controversial. Methods We depleted microgl...

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Bibliographic Details
Main Authors: Ruohe Zhao, Wanling Hu, Julia Tsai, Wei Li, Wen-Biao Gan
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Aβ plaque
Microglia depletion
Two-photon imaging
APP/PS1
CX3CR1CreER/+:R26DTR/+
Online Access:http://link.springer.com/article/10.1186/s13024-017-0188-6

Internet

http://link.springer.com/article/10.1186/s13024-017-0188-6

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