Conformational Change of Amyloid-β 40 in Association with Binding to GM1-Glycan Cluster
Abstract Aggregates of amyloid-β (Aβ) peptide are well known to be the causative substance of Alzheimer’s disease (AD). Recent studies showed that monosialotetrahexosylganglioside (GM1) clusters induce the pathological aggregation of Aβ peptide responsible for the onset and development of AD. Howeve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-43117-6 |