Core aldehydes of alkyl glycerophosphocholines in atheroma induce platelet aggregation and inhibit endothelium-dependent arterial relaxation

Core aldehydes of alkyl glycerophosphocholines in atheroma induce platelet aggregation and inhibit endothelium-dependent arterial relaxation

Plaque disruption with superimposed thrombosis is considered to be responsible for precipitating acute coronary syndrome. We identified sn-1-alkyl- and sn-1-acyl-type glycerophosphocholine (GroPCho) core aldehydes from human atheromas and demonstrated their activities on platelets and arteries. The...

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Bibliographic Details
Main Authors: Hiroshi Kamido, Hiroyuki Eguchi, Hisao Ikeda, Tsutomu Imaizumi, Kazunari Yamana, Karsten Hartvigsen, Amir Ravandi, Arnis Kuksis
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Journal of Lipid Research
Subjects:
acute coronary syndrome
glycerophosphocholine
lipid peroxidation
mass spectrometry
phospholipid
platelet-activating factor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520301991

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http://www.sciencedirect.com/science/article/pii/S0022227520301991

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