Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient

Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient

We will present a 42-year-old woman with acute myeloid leukemia and pulmonary aspergillosis. She was treated with several antifungal agents, including three triazoles. Voriconazole, posaconazole, and isavuconazole all led to hepatocellular liver injury. Voriconazole administration led to a peak alan...

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Bibliographic Details
Main Authors: Tim Bühler, Michael Medinger, Jamal Bouitbir, Stephan Krähenbühl, Anne Leuppi-Taegtmeyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
azole antifungal agents
voriconazole
posaconazole
isavuconazole
hepatotoxicity
drug-induced liver injury (DILI)
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00645/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00645/full

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