Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion

Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion

Intranasal (IN) administration appears to be a suitable route for clinical use as it allows direct delivery of bioactive molecules to the central nervous system, reducing systemic exposure and sides effects. Nevertheless, only some molecules can be transported to the brain from the nasal cavity. Thi...

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Bibliographic Details
Main Authors: Asma Cherait, Julie Maucotel, Benjamin Lefranc, Jérôme Leprince, David Vaudry
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Endocrinology
Subjects:
pituitary adenylate cyclase-activating polypeptide
intranasal administration
cerebral ischemia
infarct volume
functional recovery
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.585082/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.585082/full

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