The Role of Non-Native Interactions in the Folding of Knotted Proteins: Insights from Molecular Dynamics Simulations

The Role of Non-Native Interactions in the Folding of Knotted Proteins: Insights from Molecular Dynamics Simulations

For several decades, the presence of knots in naturally-occurring proteins was largely ruled out a priori for its supposed incompatibility with the efficiency and robustness of folding processes. For this very same reason, the later discovery of several unrelated families of knotted proteins motivat...

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Bibliographic Details
Main Authors: Roberto Covino, Tatjana Škrbić, Silvio a Beccara, Pietro Faccioli, Cristian Micheletti
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Biomolecules
Subjects:
knotted proteins
folding simulations
non-native interactions
Online Access:http://www.mdpi.com/2218-273X/4/1/1

Internet

http://www.mdpi.com/2218-273X/4/1/1

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