NKCS, a Mutant of the NK-2 Peptide, Causes Severe Distortions and Perforations in Bacterial, But Not Human Model Lipid Membranes

NKCS, a Mutant of the NK-2 Peptide, Causes Severe Distortions and Perforations in Bacterial, But Not Human Model Lipid Membranes

NKCS is an improved mutant of the bioactive peptide NK-2, which shows strong activity against Escherichia coli and low toxicity towards human cells. The different activity demonstrates the relevance of the physico-chemical nature of the target membrane for the biological effect of this peptide. We s...

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Bibliographic Details
Main Authors: Corina Ciobanasu, Agnieszka Rzeszutek, Ulrich Kubitscheck, Regine Willumeit
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Molecules
Subjects:
antimicrobial peptides
membrane distortion
membrane perforation
phosphatidylethanolamine
Online Access:http://www.mdpi.com/1420-3049/20/4/6941

Internet

http://www.mdpi.com/1420-3049/20/4/6941

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