Computational discovery of dynamic cell line specific Boolean networks from multiplex time-course data.

Protein signaling networks are static views of dynamic processes where proteins go through many biochemical modifications such as ubiquitination and phosphorylation to propagate signals that regulate cells and can act as feed-back systems. Understanding the precise mechanisms underlying protein inte...

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Bibliographic Details
Main Authors: Misbah Razzaq, Loïc Paulevé, Anne Siegel, Julio Saez-Rodriguez, Jérémie Bourdon, Carito Guziolowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006538