An Advanced Systems Pharmacology Strategy Reveals AKR1B1, MMP2, PTGER3 as Key Genes in the Competing Endogenous RNA Network of Compound Kushen Injection Treating Gastric Carcinoma by Integrated Bioinformatics and Experimental Verification

An Advanced Systems Pharmacology Strategy Reveals AKR1B1, MMP2, PTGER3 as Key Genes in the Competing Endogenous RNA Network of Compound Kushen Injection Treating Gastric Carcinoma by Integrated Bioinformatics and Experimental Verification

Gastric carcinoma (GC) is a severe tumor of the digestive tract with high morbidity and mortality and poor prognosis, for which novel treatment options are urgently needed. Compound Kushen injection (CKI), a classical injection of Chinese medicine, has been widely used to treat various tumors in cli...

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Bibliographic Details
Main Authors: Wei Zhou, Chao Wu, Chongjun Zhao, Zhihong Huang, Shan Lu, Xiaotian Fan, Yingying Tan, Antony Stalin, Rongli You, Xinkui Liu, Jingyuan Zhang, Zhishan Wu, Jiarui Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
compound Kushen injection
gastric cancer
ceRNA network
system pharmacology
meta-analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.742421/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.742421/full

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