Long-Term Neuroanatomical Consequences of Childhood Maltreatment: Reduced Amygdala Inhibition by Medial Prefrontal Cortex

Long-Term Neuroanatomical Consequences of Childhood Maltreatment: Reduced Amygdala Inhibition by Medial Prefrontal Cortex

Similar to patients with Major depressive disorder (MDD), healthy subjects at risk for depression show hyperactivation of the amygdala as a response to negative emotional expressions. The medial prefrontal cortex is responsible for amygdala control. Analyzing a large cohort of healthy subjects, we a...

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Bibliographic Details
Main Authors: Roman Kessler, Simon Schmitt, Torsten Sauder, Frederike Stein, Dilara Yüksel, Dominik Grotegerd, Udo Dannlowski, Tim Hahn, Astrid Dempfle, Jens Sommer, Olaf Steinsträter, Igor Nenadic, Tilo Kircher, Andreas Jansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Systems Neuroscience
Subjects:
major depression
childhood maltreatment
fMRI
connectivity
emotion processing
dynamic causal modeling
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2020.00028/full

Internet

https://www.frontiersin.org/article/10.3389/fnsys.2020.00028/full

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