Irradiation promotes an M2 macrophage phenotype in tumor hypoxia

Irradiation promotes an M2 macrophage phenotype in tumor hypoxia

Macrophages display different phenotypes with distinct functions and can rapidly respond to environmental changes. Previous studies on TRAMP-C1 tumor model have shown that irradiation has a strong impact on tumor microenvironments. The major changes include the decrease of microvascular density (MVD...

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Bibliographic Details
Main Authors: Chi-Shiun eChiang, Sheng-Yung eFu, Shu-Chi eWang, Ching-Fang eYu, Fang-Hsin eChen, Chi-Min eLin, Ji-Hong eHong
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Oncology
Subjects:
Glioma
Radiation
hypoxia
Tumor microenvironments
Tumor-associated macrophages
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00089/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00089/full

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