Parkin- and PINK1-dependent mitophagy in neurons: Will the real pathway please stand up?
Parkinson’s disease (PD) is characterized by massive degeneration of dopaminergic neurons in the substantia nigra. Whereas the majority of PD cases are sporadic, about 5 to 10 percent of cases are familial and associated with genetic factors. The loss of parkin or PINK1, two such factors, leads to a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00100/full |