Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study

Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study

Abstract Background In gout, long-term urate-lowering therapy (ULT) promotes dissolution of tissue urate crystal deposits. However, no studies using combined xanthine oxidase inhibition and uricosuric ULT have focused on clinical outcomes or adverse events (AEs) beyond 12 months of therapy. Our obje...

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Bibliographic Details
Main Authors: Nicola Dalbeth, Graeme Jones, Robert Terkeltaub, Dinesh Khanna, Maple Fung, Scott Baumgartner, Fernando Perez-Ruiz
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Arthritis Research & Therapy
Subjects:
Extension study
Febuxostat
Gout
Lesinurad
Phase III trial
Serum urate
Online Access:http://link.springer.com/article/10.1186/s13075-018-1788-4

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http://link.springer.com/article/10.1186/s13075-018-1788-4

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