Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents

Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents

In this study, the antinociceptive properties of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives 5a–i at doses of 25 and 50 mg/kg were evaluated in mice, using the abdominal constriction test. Molecular modeling studies were also performed using density functional theory calculati...

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Bibliographic Details
Main Authors: Francisco J. B. Mendonça Junior, Sebastião J. de Melo, Elisa Soares Leite, Almir G. Wanderley, Luciana Scotti, Marcus T. Scotti, João H. Costa-Silva, Janaína V. dos Anjos, Rajendra M. Srivastava
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:Molecules
Subjects:
4-(3H)-pyrimidinones
antinociceptive activity
molecular modeling
density functional theory
Online Access:http://www.mdpi.com/1420-3049/17/1/809/

Internet

http://www.mdpi.com/1420-3049/17/1/809/

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