Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice

Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice

We investigated whether peripheral combination treatment of a sodium–glucose cotransporter 2 (SGLT2) inhibitor and leptin improves glucose metabolism in insulin-dependent diabetes mellitus (IDDM) model mice. Twelve-week-old male C57BL6 mice were intraperitoneally administered a high dose of streptoz...

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Bibliographic Details
Main Authors: Hiroshi Yaginuma, Ryoichi Banno, Runan Sun, Keigo Taki, Akira Mizoguchi, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Hiroshi Arima
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Pharmacological Sciences
Subjects:
SGLT2 inhibitor
Leptin
IDDM
Glucose metabolism
β-hydroxybutyrate
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000852

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http://www.sciencedirect.com/science/article/pii/S1347861321000852

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