Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues
A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells. The discovery and characterization of several inhibitory and activating receptors unveiled most of the mechanisms allowing NK cells to spare he...
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doaj-dd83e38de9a34bcda308bc5eb0177a912020-11-25T02:31:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-10-01910.3389/fimmu.2018.02324415773Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human TissuesRoberta Castriconi0Roberta Castriconi1Paolo Carrega2Alessandra Dondero3Francesca Bellora4Beatrice Casu5Stefano Regis6Guido Ferlazzo7Cristina Bottino8Cristina Bottino9Dipartimento di Medicina Sperimentale, University of Genova, Genova, ItalyCentro di Eccellenza per la Ricerca Biomedica, University of Genova, Genova, ItalyDipartimento di Patologia Umana, University of Messina, Messina, ItalyDipartimento di Medicina Sperimentale, University of Genova, Genova, ItalyDipartimento di Medicina Sperimentale, University of Genova, Genova, ItalyDipartimento di Medicina Sperimentale, University of Genova, Genova, ItalyIstituto di ricovero e cura a carattere scientifico (IRCCS) Giannina Gaslini, Genova, ItalyDipartimento di Patologia Umana, University of Messina, Messina, ItalyDipartimento di Medicina Sperimentale, University of Genova, Genova, ItalyIstituto di ricovero e cura a carattere scientifico (IRCCS) Giannina Gaslini, Genova, ItalyA large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells. The discovery and characterization of several inhibitory and activating receptors unveiled most of the mechanisms allowing NK cells to spare healthy cells while selectively attacking abnormal tissues. Nevertheless, the mechanisms ruling NK cell subset recirculation among the different compartments of human body have only lately started to be investigated. This is particularly true for pathological settings such as tumors or infected tissues but also for para-physiological condition like pregnant human uterine mucosa. It is becoming evident that the microenvironment associated to a particular clinical condition can deeply influence the migratory capabilities of NK cells. In this review we describe the main mechanisms and stimuli known to regulate the expression of chemokine receptors and other molecules involved in NK cell homing to either normal or pathological/inflamed tissues, including tumors or organs such as lung and liver. We will also discuss the role played by the chemokine/chemokine receptor axes in the orchestration of physiological events such as NK cell differentiation, lymphoid organ retention/egress and recruitment to decidua during pregnancy.https://www.frontiersin.org/article/10.3389/fimmu.2018.02324/fullnatural killer cellschemokines and chemokine receptorsmigration and residencytumor and inflammationpregnancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberta Castriconi Roberta Castriconi Paolo Carrega Alessandra Dondero Francesca Bellora Beatrice Casu Stefano Regis Guido Ferlazzo Cristina Bottino Cristina Bottino |
spellingShingle |
Roberta Castriconi Roberta Castriconi Paolo Carrega Alessandra Dondero Francesca Bellora Beatrice Casu Stefano Regis Guido Ferlazzo Cristina Bottino Cristina Bottino Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues Frontiers in Immunology natural killer cells chemokines and chemokine receptors migration and residency tumor and inflammation pregnancy |
author_facet |
Roberta Castriconi Roberta Castriconi Paolo Carrega Alessandra Dondero Francesca Bellora Beatrice Casu Stefano Regis Guido Ferlazzo Cristina Bottino Cristina Bottino |
author_sort |
Roberta Castriconi |
title |
Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues |
title_short |
Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues |
title_full |
Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues |
title_fullStr |
Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues |
title_full_unstemmed |
Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues |
title_sort |
molecular mechanisms directing migration and retention of natural killer cells in human tissues |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-10-01 |
description |
A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells. The discovery and characterization of several inhibitory and activating receptors unveiled most of the mechanisms allowing NK cells to spare healthy cells while selectively attacking abnormal tissues. Nevertheless, the mechanisms ruling NK cell subset recirculation among the different compartments of human body have only lately started to be investigated. This is particularly true for pathological settings such as tumors or infected tissues but also for para-physiological condition like pregnant human uterine mucosa. It is becoming evident that the microenvironment associated to a particular clinical condition can deeply influence the migratory capabilities of NK cells. In this review we describe the main mechanisms and stimuli known to regulate the expression of chemokine receptors and other molecules involved in NK cell homing to either normal or pathological/inflamed tissues, including tumors or organs such as lung and liver. We will also discuss the role played by the chemokine/chemokine receptor axes in the orchestration of physiological events such as NK cell differentiation, lymphoid organ retention/egress and recruitment to decidua during pregnancy. |
topic |
natural killer cells chemokines and chemokine receptors migration and residency tumor and inflammation pregnancy |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2018.02324/full |
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