Continuous Microevolution Accelerates Disease Progression during Sequential Episodes of Infection

Summary: Bacteria adapt to dynamic changes in the host during chronic and recurrent infections. Bacterial microevolution is one type of adaptation that imparts a selective advantage. We hypothesize that recurrent episodes of disease promote microevolution through genetic mutations that modulate dise...

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Bibliographic Details
Main Authors: Alistair Harrison, Rachael L. Hardison, Audra R. Fullen, Rachel M. Wallace, David M. Gordon, Peter White, Ryan N. Jennings, Sheryl S. Justice, Kevin M. Mason
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472030173X