Enhanced Production of Vitamin K2 from Bacillus subtilis (natto)by Mutation and Optimization of the Fermentation Medium

The aim of this study was to enhance the production of vitamin K2 by using N-methyl-N-nitro-N-nitroso-guanidine (NTG) and low energy ion beam implantation and optimizing the fermentation medium. Mutation resulted in 1.66-fold higher production of vitamin K2 than that of the parentl strain. The produ...

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Bibliographic Details
Main Authors: Junying Song, Hongxia Liu, Li Wang, Jun Dai, Yan Liu, Hui Liu, Genhai Zhao, Peng Wang, Zhiming Zheng
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2014-08-01
Series:Brazilian Archives of Biology and Technology
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000400606&lng=en&tlng=en