Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4

Abstract Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention. Pharmacological inhibition of the bromodomain and extraterminal (BET) family of chromatin adapter proteins has proven effective in this reg...

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Bibliographic Details
Main Authors: Jack Calder, Amy Nagelberg, Jennifer Luu, Daniel Lu, William W. Lockwood
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-021-00316-z