Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation

Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation

1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a–h and glycine alkyl esters 2a–c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa–ea in good yields. The γ-carbolines are fluoresce...

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Bibliographic Details
Main Authors: Premansh Dudhe, Mena Asha Krishnan, Kratika Yadav, Diptendu Roy, Krishnan Venkatasubbaiah, Biswarup Pathak, Venkatesh Chelvam
Format: Article
Language:English
Published: Beilstein-Institut 2021-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
γ-carboline
cascade reaction
cell uptake
cytotoxicity
fluorescence
Online Access:https://doi.org/10.3762/bjoc.17.101

Internet

https://doi.org/10.3762/bjoc.17.101

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