Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window

Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window

There is a critical window for estrogen replacement therapy, beyond which estradiol (E2) fails to enhance cognition and N-methyl-D-aspartate (NMDA) receptor function, and E2-responsive transcription decreases. Much less attention has been given to the mechanism for closing of the critical window, wh...

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Bibliographic Details
Main Authors: Puja Sinha, Asha Rani, Ashok Kumar, Alberto Riva, Jason Orr Brant, Thomas C. Foster
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
estrogen
hippocampus
aging
DNA methylation
critical window
NMDA receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.717032/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.717032/full

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