Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

Malaria-specific antibody responses are short lived in children, leaving them susceptible to repeated bouts of febrile malaria. The cellular and molecular mechanisms underlying this apparent immune deficiency are poorly understood. Recently, T follicular helper (Tfh) cells have been shown to play a...

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Bibliographic Details
Main Authors: Nyamekye Obeng-Adjei, Silvia Portugal, Tuan M. Tran, Takele B. Yazew, Jeff Skinner, Shanping Li, Aarti Jain, Philip L. Felgner, Ogobara K. Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter D. Crompton
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715010153

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http://www.sciencedirect.com/science/article/pii/S2211124715010153

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