Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice.

Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice.

Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension receptor blockade (ARB) has excellent therapeutic potential in DMD based on recent data demonstrating attenuation of skeletal muscle disease progre...

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Bibliographic Details
Main Authors: Lawrence T Bish, Mark Yarchoan, Meg M Sleeper, Jeffrey A Gazzara, Kevin J Morine, Pedro Acosta, Elisabeth R Barton, H Lee Sweeney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3120761?pdf=render

Internet

http://europepmc.org/articles/PMC3120761?pdf=render

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