Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons

Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons

SHANK2 is a scaffold protein that serves as a protein anchor at the postsynaptic density in neurons. Genetic variants of SHANK2 are strongly associated with synaptic dysfunction and the pathophysiology of autism spectrum disorder. Recent studies indicate that early neuronal developmental defects pla...

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Bibliographic Details
Main Authors: Shu-Ting Chen, Wan-Jing Lai, Wei-Jia Zhang, Qing-Pei Chen, Li-Bing Zhou, Kwok-Fai So, Ling-Ling Shi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
cells; factor; growth; in vitro; model; neural differentiation; neurogenesis; plasticity
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=12;spage=2335;epage=2343;aulast=Chen

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=12;spage=2335;epage=2343;aulast=Chen

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