An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel
Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction, but conformational changes associated with gating remained unknown. Here authors use high-speed atomic force microscopy to visualize SthK channels dynamics in response to cyclic nucleotides.
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06414-8 |