Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.

Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.

Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. This study wa...

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Bibliographic Details
Main Authors: Huzoor Akbar, Xun Shang, Rehana Perveen, Mark Berryman, Kevin Funk, James F Johnson, Narendra N Tandon, Yi Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3138762?pdf=render

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http://europepmc.org/articles/PMC3138762?pdf=render

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