Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice

Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice

We generated myeloid specific sphingosine-1-phosphate receptor 1 (S1pr1) deficient mice by crossing mice that had myeloid specific expression of Cre recombinase (lyzMCre) with mice having the S1pr1 gene flanked by loxP recombination sites. We transplanted bone marrow from these mice and control lyzM...

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Bibliographic Details
Main Authors: Leticia Gonzalez, Alexander S. Qian, Usama Tahir, Pei Yu, Bernardo L. Trigatti
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
atherosclerosis
HDL
macrophage
mouse model
sphingosine-1-phosphate receptor 1
Online Access:https://www.mdpi.com/1422-0067/18/12/2721

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https://www.mdpi.com/1422-0067/18/12/2721

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