Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage

Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage

Lumisterol (L3) is a stereoisomer of 7-dehydrocholesterol and is produced through the photochemical transformation of 7-dehydrocholesteol induced by high doses of UVB. L3 is enzymatically hydroxylated by CYP11A1, producing 20(OH)L3, 22(OH)L3, 20,22(OH)2L3, and 24(OH)L3. Hydroxylumisterols function a...

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Bibliographic Details
Main Authors: Anyamanee Chaiprasongsuk, Zorica Janjetovic, Tae-Kang Kim, Cynthia J. Schwartz, Robert C. Tuckey, Edith K. Y. Tang, Chander Raman, Uraiwan Panich, Andrzej T. Slominski
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
photobiology
UV radiation
keratinocyte
inflammation
cell differentiation
lumisterol hydroxyderivatives
Online Access:https://www.mdpi.com/1422-0067/21/24/9374

Internet

https://www.mdpi.com/1422-0067/21/24/9374

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