Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis

Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis

Cystathionine-γ-lyase (CSE) is a hydrogen sulfide (H<sub>2</sub>S)-synthesizing enzyme that promotes inflammation by upregulating H<sub>2</sub>S in sepsis. Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells (liver sieve) that undergo alteration durin...

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Bibliographic Details
Main Authors: Ravinder R Gaddam, Stephen Chambers, Robin Fraser, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
hydrogen sulfide
substance P
cystathionine-gamma-lyase
neurokinin-1 receptor
liver sieve
Online Access:https://www.mdpi.com/1422-0067/20/13/3191

Internet

https://www.mdpi.com/1422-0067/20/13/3191

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