Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Zfp335bloto/bloto mice exhibit a naïve...

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Bibliographic Details
Main Authors: Brenda Y Han, Shuang Wu, Chuan-Sheng Foo, Robert M Horton, Craig N Jenne, Susan R Watson, Belinda Whittle, Chris C Goodnow, Jason G Cyster
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
T cell development
thymocytes
transcription factor
ENU mutagenesis
t cell
Online Access:https://elifesciences.org/articles/03549

Internet

https://elifesciences.org/articles/03549

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