The mechanistic insight of a specific interaction between 15d-Prostaglandin-J2 and eIF4A suggests an evolutionary conserved role across species

The mechanistic insight of a specific interaction between 15d-Prostaglandin-J2 and eIF4A suggests an evolutionary conserved role across species

15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) is an anti-inflammatory/anti-neoplastic prostaglandin that functions through covalent binding to cysteine residues of various target proteins. We previously showed that 15d-PGJ2 mediated anti-inflammatory responses are dependent on the translational i...

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Bibliographic Details
Main Authors: So Jeong Yun, Hyunjoon Kim, Seung-Hyun Jung, Joon Hyun Kim, Jeong Eun Ryu, N. Jiten Singh, Jouhyun Jeon, Jin-Kwan Han, Cheol-Hee Kim, Sanguk Kim, Sung Key Jang, Woo Jae Kim
Format: Article
Language:English
Published: The Company of Biologists 2018-11-01
Series:Biology Open
Subjects:
15d-PGJ2
eIF4A
Inflammation
Prostaglandins
Stress granules
Translation
Online Access:http://bio.biologists.org/content/7/11/bio035402

Internet

http://bio.biologists.org/content/7/11/bio035402

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