Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5. We review evidence for the formation of different TRPC1/4/5 tetramers, give an overview of recently...

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Bibliographic Details
Main Authors: Aisling Minard, Claudia C. Bauer, David J. Wright, Hussein N. Rubaiy, Katsuhiko Muraki, David J. Beech, Robin S. Bon
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Cells
Subjects:
ion channel
TRPC
small molecules
calcium
chemical probes
Online Access:http://www.mdpi.com/2073-4409/7/6/52

Internet

http://www.mdpi.com/2073-4409/7/6/52

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