HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway
Abstract Background Pyroptosis is a form of proinflammatory gasdermin-mediated programmed cell death. Abnormal mucosal inflammation in the intestine is a critical risk factor for colitis-associated colorectal cancer (CAC). However, it is unknown whether pyroptosis participates in the development of...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-11-01
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Series: | Journal of Hematology & Oncology |
Online Access: | http://link.springer.com/article/10.1186/s13045-020-00985-0 |