HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Abstract Background Pyroptosis is a form of proinflammatory gasdermin-mediated programmed cell death. Abnormal mucosal inflammation in the intestine is a critical risk factor for colitis-associated colorectal cancer (CAC). However, it is unknown whether pyroptosis participates in the development of...

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Bibliographic Details
Main Authors: Gao Tan, Chongyang Huang, Jiaye Chen, Fachao Zhi
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Hematology & Oncology
Online Access:http://link.springer.com/article/10.1186/s13045-020-00985-0

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http://link.springer.com/article/10.1186/s13045-020-00985-0

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