Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G protei...

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Bibliographic Details
Main Authors: Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03522-3

Internet

https://doi.org/10.1038/s41467-018-03522-3

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