Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G protei...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03522-3 |