Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G protei...
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Nature Publishing Group
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03522-3 |
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doaj-ddb2e76a96254f8299931ae5586deefc2021-05-11T10:06:10ZengNature Publishing GroupNature Communications2041-17232018-03-019111210.1038/s41467-018-03522-3Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclaseGemma Navarro0Arnau Cordomí1Verónica Casadó-Anguera2Estefanía Moreno3Ning-Sheng Cai4Antoni Cortés5Enric I. Canela6Carmen W. Dessauer7Vicent Casadó8Leonardo Pardo9Carme Lluís10Sergi Ferré11Department of Biochemistry and Physiology of the Faculty of Pharmacy of the University of BarcelonaLaboratory of Computational Medicine, School of Medicine, Autonomous University of BarcelonaDepartment of Biochemistry and Molecular Biomedicine of the Faculty of Biology and Institute of Biomedicine of the University of Barcelona and Center for Biomedical Research in Neurodegenerative Diseases NetworkDepartment of Biochemistry and Molecular Biomedicine of the Faculty of Biology and Institute of Biomedicine of the University of Barcelona and Center for Biomedical Research in Neurodegenerative Diseases NetworkIntegrative Neurobiology Section, National Institute on Drug Abuse, National Institutes of HealthDepartment of Biochemistry and Molecular Biomedicine of the Faculty of Biology and Institute of Biomedicine of the University of Barcelona and Center for Biomedical Research in Neurodegenerative Diseases NetworkDepartment of Biochemistry and Molecular Biomedicine of the Faculty of Biology and Institute of Biomedicine of the University of Barcelona and Center for Biomedical Research in Neurodegenerative Diseases NetworkDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science CenterDepartment of Biochemistry and Molecular Biomedicine of the Faculty of Biology and Institute of Biomedicine of the University of Barcelona and Center for Biomedical Research in Neurodegenerative Diseases NetworkLaboratory of Computational Medicine, School of Medicine, Autonomous University of BarcelonaDepartment of Biochemistry and Molecular Biomedicine of the Faculty of Biology and Institute of Biomedicine of the University of Barcelona and Center for Biomedical Research in Neurodegenerative Diseases NetworkIntegrative Neurobiology Section, National Institute on Drug Abuse, National Institutes of HealthIt is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G proteins and AC5.https://doi.org/10.1038/s41467-018-03522-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gemma Navarro Arnau Cordomí Verónica Casadó-Anguera Estefanía Moreno Ning-Sheng Cai Antoni Cortés Enric I. Canela Carmen W. Dessauer Vicent Casadó Leonardo Pardo Carme Lluís Sergi Ferré |
| spellingShingle |
Gemma Navarro Arnau Cordomí Verónica Casadó-Anguera Estefanía Moreno Ning-Sheng Cai Antoni Cortés Enric I. Canela Carmen W. Dessauer Vicent Casadó Leonardo Pardo Carme Lluís Sergi Ferré Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase Nature Communications |
| author_facet |
Gemma Navarro Arnau Cordomí Verónica Casadó-Anguera Estefanía Moreno Ning-Sheng Cai Antoni Cortés Enric I. Canela Carmen W. Dessauer Vicent Casadó Leonardo Pardo Carme Lluís Sergi Ferré |
| author_sort |
Gemma Navarro |
| title |
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase |
| title_short |
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase |
| title_full |
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase |
| title_fullStr |
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase |
| title_full_unstemmed |
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase |
| title_sort |
evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-03-01 |
| description |
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G proteins and AC5. |
| url |
https://doi.org/10.1038/s41467-018-03522-3 |
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