Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement

Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement

Abstract Introduction Intranasal deferoxamine (IN DFO) has been shown to decrease memory loss and have beneficial impacts across several models of neurologic disease and injury, including rodent models of Alzheimer's and Parkinson's disease. Methods In order to assess the mechanism of DFO,...

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Bibliographic Details
Main Authors: Jared M. Fine, Jacob Kosyakovsky, Amanda M. Baillargeon, Julian V. Tokarev, Jacob M. Cooner, Aleta L. Svitak, Katherine A. Faltesek, William H. Frey II, Leah R. Hanson
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Brain and Behavior
Subjects:
deferoxamine
glycogen synthase kinase 3β
hypoxia‐inducible factor 1α
intranasal
memory enhancement
radial arm water maze
Online Access:https://doi.org/10.1002/brb3.1536

Internet

https://doi.org/10.1002/brb3.1536

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