Conditional HIF-1alpha expression produces a reversible cardiomyopathy.

Conditional HIF-1alpha expression produces a reversible cardiomyopathy.

The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1alpha. Cardiac function steadily decreased with tra...

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Bibliographic Details
Main Authors: Raffi Bekeredjian, Chad B Walton, Keith A MacCannell, Jennifer Ecker, Fred Kruse, Joel T Outten, David Sutcliffe, Robert D Gerard, Richard K Bruick, Ralph V Shohet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2908132?pdf=render

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http://europepmc.org/articles/PMC2908132?pdf=render

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