Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

Abstract Background Epigenetic modifications, including DNA methylation, play an important role in gene silencing and genome stability. Consequently, epigenetic dysregulation can cause several diseases, such as cancer, obesity, diabetes, autism, and imprinting disorders. Results We validate three me...

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Bibliographic Details
Main Authors: Takuro Horii, Sumiyo Morita, Shinjiro Hino, Mika Kimura, Yuko Hino, Hiroshi Kogo, Mitsuyoshi Nakao, Izuho Hatada
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Genome Biology
Subjects:
CRISPR/Cas9
dCas9
Epigenome editing
Silver-Russell syndrome
Demethylation
Online Access:http://link.springer.com/article/10.1186/s13059-020-01991-8

Internet

http://link.springer.com/article/10.1186/s13059-020-01991-8

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