Tunable Composition of Dynamic Non-Viral Vectors over the DNA Polyplex Formation and Nucleic Acid Transfection

Tunable Composition of Dynamic Non-Viral Vectors over the DNA Polyplex Formation and Nucleic Acid Transfection

Polyethylene glycol (PEG) functionalization of non-viral vectors represents a powerful tool through the formation of an overall surface charge shielding ability, which is fundamental for efficient nucleic acid delivery systems. The degree of non-viral vector PEGylation and the molecular weight of ut...

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Bibliographic Details
Main Authors: Lilia Clima, Bogdan Florin Craciun, Gabriela Gavril, Mariana Pinteala
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Polymers
Subjects:
polyethyleneglycol
polyethyleneimine
pegylated squalene
dynamic combinatorial chemistry
pDNA condensation
non-viral vectors
gene therapy
DNA transfection
Online Access:https://www.mdpi.com/2073-4360/11/8/1313

Internet

https://www.mdpi.com/2073-4360/11/8/1313

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