Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

Studies in humans and mice have shown that increased expression of apolipoprotein C-I (apoC-I) results in combined hyperlipidemia with a more pronounced effect on triglycerides (TGs) compared with total cholesterol (TC). The aim of this study was to elucidate the main reason for this effect using hu...

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Bibliographic Details
Main Authors: Jimmy F.P. Berbée, Caroline C. van der Hoogt, Deepa Sundararaman, Louis M. Havekes, Patrick C.N. Rensen
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Journal of Lipid Research
Subjects:
fatty acids
lipid metabolism
triglycerides
apolipoprotein C-I
very low density lipoprotein
lipoprotein lipase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520340633

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http://www.sciencedirect.com/science/article/pii/S0022227520340633

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