Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty LiverSummary

Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty LiverSummary

Background & Aims: Fatty liver or nonalcoholic fatty liver disease (NAFLD) is the most common liver disease associated with comorbidities such as insulin resistance and cardiovascular and metabolic diseases. Chronic activation of hypoxic signaling, in particular, hypoxia-inducible factor (HI...

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Bibliographic Details
Main Authors: Raja Gopal Reddy Mooli, Jessica Rodriguez, Shogo Takahashi, Sumeet Solanki, Frank J. Gonzalez, Sadeesh K. Ramakrishnan, Yatrik M. Shah
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
ERK
MEK
PPARα
Hypoxia
HIF
Fatty Liver
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21000631

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X21000631

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