Novel Iron-Chelator DIBI Inhibits Staphylococcus aureus Growth, Suppresses Experimental MRSA Infection in Mice and Enhances the Activities of Diverse Antibiotics in vitro

Novel Iron-Chelator DIBI Inhibits Staphylococcus aureus Growth, Suppresses Experimental MRSA Infection in Mice and Enhances the Activities of Diverse Antibiotics in vitro

DIBI, a purpose-designed hydroxypyridinone-containing iron-chelating antimicrobial polymer was studied for its anti-staphylococcal activities in vitro in comparison to deferiprone, the chemically related, small molecule hydroxypyridinone chelator. The sensitivities of 18 clinical isolates of Staphyl...

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Bibliographic Details
Main Authors: Maria del Carmen Parquet, Kimberley A. Savage, David S. Allan, Ross J. Davidson, Bruce E. Holbein
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
iron chelator
Staphylococcus aureus
DIBI
antibiotic
hydroxypyridinone
deferiprone
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01811/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01811/full

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