Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

In sickle cell disease (SCD), higher whole blood viscosity is a risk factor for vaso-occlusive crisis, avascular necrosis, and proliferative retinopathy. Blood viscosity is strongly impacted by hemoglobin (Hb) levels and red blood cell (RBC) deformability. Voxelotor is a hemoglobin S (HbS) polymeriz...

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Bibliographic Details
Main Authors: Celeste K. Kanne, Danitza Nebor, Mira Pochron, Donna Oksenberg, Vivien A. Sheehan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
voxelotor
GBT1118
viscosity
deformability
red cell
sickle cell disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.742784/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.742784/full

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