Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway

Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway

Abstract Background Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α2-adrenergic agonist sedative, has been found to have protective effects against acute kidney injury and remote lung injury. We sought to...

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Bibliographic Details
Main Authors: Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu, Jianteng Gu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Translational Medicine
Subjects:
Renal ischemia–reperfusion
Acute lung injury
α2-Adrenoceptor
Akt pathway
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12967-018-1455-1

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http://link.springer.com/article/10.1186/s12967-018-1455-1

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