SONAR: A high-throughput pipeline for inferring antibody ontogenies from longitudinal sequencing of B cell transcripts

SONAR: A high-throughput pipeline for inferring antibody ontogenies from longitudinal sequencing of B cell transcripts

The rapid advance of massively parallel or next-generation sequencing technologies has made possible the characterization of B cell receptor repertoires in ever greater detail, leading to a proliferation of software tools for processing and annotating this data. Of especial interest, however, is the...

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Bibliographic Details
Main Authors: Chaim A Schramm, Zizhang Sheng, Zhenhai Zhang, John R Mascola, Peter D Kwong, Lawrence Shapiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Next-generation sequencing
Antibody repertoire
antibody maturation
longitudinal analysis
antibody lineage
b cell ontogeny
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00372/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00372/full

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