Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Here, using proteomics and cell-based assays, the authors show that HIV accessory protein Vpr mediates the degradation of host lysosomal-associated transmembrane protein 5 (LAPTM5) in monocyte-derived macrophages (MDM) to enhance infection in macrophages.

Bibliographic Details
Main Authors: Li Zhao, Shumei Wang, Meng Xu, Yang He, Xiaowei Zhang, Ying Xiong, Hong Sun, Haibo Ding, Wenqing Geng, Hong Shang, Guoxin Liang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24087-8

Internet

https://doi.org/10.1038/s41467-021-24087-8

Similar Items